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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 14, No. 3, 2015, pp. 545-554
Bioline Code: pr15072
Full paper language: English
Document type: Review Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 14, No. 3, 2015, pp. 545-554

 en Phytochemical, Toxicological and Pharmacological Studies of Asiasari Radix et Rhizoma: A Review
Ramalingam, Mahesh & Kim, Sung-Jin

Abstract

Herba Asari and Asiasari Radix (AR) have a centuries-old history as a folk medicine in China, Korea and Japan. AR has long been used in combination with other herbs to treat cough, toothache, headache, neuralgia, aphthous stomatitis, gingivitis, chronic bronchitis, asthma and allergies. AR from three species of the genus Asarum: A. heterotropoides check for this species in other resources Fr. Schmidt var. mandshuricum (Maxim.) Kitag., A. sieboldii check for this species in other resources Miq. var. seoulense Nakai and A. sieboldii Miq are recognized as original “Asiasari Radix et Rhizoma”. These species do not contain aristolochic acids (nephrotoxins present in the Asarum species) and therefore the roots of AR are recommended for use. Asiasari Radix is rich in volatile oils, phenylpropanoids, terpenoids, flavonoids, glycosides and lignins. The reported toxicological and pharmacological activities of AR, including antifungal, antimicrobial, antilisterial, antiallergic, acarcidal, larvicidal, anti-caries, anti-inflammatory, hepatoprotective, neuroprotective, cytotoxic and anticancer activities suggest its therapeutic potentials in drug discovery.

Keywords
Asarum; Asiasarum; Asiasarum heterotropoides var. mandshuricum; Asiasarum sieboldii Herba Asari; Folk medicine; Pharmacological; Toxicological

 
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