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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 14, No. 4, 2015, pp. 575-582
Bioline Code: pr15075
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 14, No. 4, 2015, pp. 575-582

 en Development and Evaluation of Solid Self Nano- Emulsifying Formulation of Rosuvastatin Calcium for Improved Bioavailability
Kulkarni, Nilesh S.; Ranpise, Nisharani S. & Mohan, Govind

Abstract

Purpose: To develop rosuvastatin calcium-loaded self-nanoemulsifying powder for improved oral delivery of the drug.
Methods: Solubility study was carried out in different oils, surfactants and co-surfactants. Based on the solubility study, liquid formulations were prepared using LAS/Capryol 90: Maisine 35-1 as oil phase and Tween 20 with Lutrol E400 as surfactant mixture (Smix). The liquid formulations were adsorbed onto Aerosil 200 in a ratio of 1: 0.25 % w/w to convert them into a solid form. The formulations were evaluated for globule size, zeta potential, and emulsion properties. Transmittance study, scanning electron microscopy, and in-vitro dissolution studies were carried out. Biochemical studies were carried out using a triton-induced hyperlipidemia model in Wistar rats.
Results: The developed formulations exhibited some desirable characteristics of self-emulsifying systems with nano-sized globules in the range 119.8 to 228.9 nm, rapid emulsification in approximately 60 s and transmittance of close to 100 %. In-vitro dissolution studies on the developed formulations indicate a 4-fold increase in drug release in 10 min, compared to the pure drug (ROC) while pharmacodynamic data showed significant improvement in oral bioavailability compared to the pure drug.
Conclusion: The developed formulation containing the oils, LAS and combination of capryol 90 with Maisine 35-1, has the capability to improve the solubility and bioavailability of rosuvastatin calcium when formulated as a self-nanoemulsifying product.

Keywords
Rosuvastatin; Particle size; Zeta potential; Nanoemulsion; Oral bioavailability; Hyperlipidemia; Pharmacodynamics; Surfactants; Co-surfactants

 
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