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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 14, No. 4, 2015, pp. 605-609
Bioline Code: pr15079
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 14, No. 4, 2015, pp. 605-609

 en Inhibition of Fungal Aflatoxin B1 Biosynthesis by Diverse Botanically-Derived Polyphenols
Zhou, Wei; Hu, Liang-Bin; Zhao, Yang; Wang, Miao-Yan; Zhang, Hao & Mo, Hai-Zhen

Abstract

Purpose: To identify and characterize the capacity of diverse botanically-derived polyphenols to inhibit aflatoxin B1 (AFB1) production by Aspergillus flavus check for this species in other resources .
Methods: A tea-derived polyphenol mixture and numerous individual polyphenols were tested for their effects on A. flavus growth and AFB1 production. Fungal spores were cultured for 60 h with polyphenols (range 0 ‒ 1,000 μg/mL). The fungi were enumerated by hemocytometry, and AFB1 in culture supernatants was quantified by high-performance liquid chromatography (HPLC).
Results: Neither the tea-derived polyphenol mixture nor individual polyphenol compound, except quercetin, inhibited A. flavus growth. Quercetin detectably inhibited growth at 800 μg/mL; none of the remaining polyphenols inhibited fungal proliferation, even at 1,000 μg/mL. However, catechin mixture and all individual polyphenols differentially inhibited fungal AFB1 biosynthesis. Non-ester catechin derivatives revealed stronger inhibitory activity than ester derivatives.
Conclusion: Quercetin exhibits the strongest inhibitory effect on AFB1 production and is the only test compound that also inhibits fungal proliferation. Botanically-derived polyphenols are, therefore, promising reagents for controlling fungal contamination and associated toxic aflatoxin deposition in harvested crops and in food processing operations.

Keywords
Polyphenols; Quercetin; Aflatoxin B1; Inhibition; Antioxidation

 
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