Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 14, No. 4, 2015, pp. 707-714
Bioline Code: pr15093
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 14, No. 4, 2015, pp. 707-714
© Copyright 2015 - Tropical Journal of Pharmaceutical Research
Rational Antimicrobial Use in an Intensive Care Unit in Jakarta, Indonesia: A Hospital-Based, Cross-Sectional Study|
Luciana; Andrajati, Retnosari; Rianti, Alfina & Khan, Amer Hayat
Purpose: To analyze the rationality of antimicrobial usage and factors influencing it over the period of
January to December 2010 in Fatmawati General Hospital, Jakarta, Indonesia.
Methods: Present study was conducted in the intensive care unit of Fatmawati General Hospital,
Jakarta, Indonesia. Gyssens method was used to assess the rationality of antimicrobial use. Data for
this retrospective, cross-sectional study were drawn from patients’ medical record files. Multivariate
analysis with ordinal logistic regression was used to determine the dominant factors affecting the
appropriateness of antimicrobial use.
Results: Data for 410 patients from the intensive care unit (ICU) was collected. There were 912
antimicrobial regimens prescribed for these patients. Based on Gyssens method, 805 antimicrobial
regimens were empirical and 107 definitive. Of the empirical regimens, 596 (74.03 %) were
inappropriate, while of the definitive regimens, 84 (78.51 %) were inappropriate. Site of infection,
comorbid conditions and economic status of patients were the main factors that influenced the
appropriateness of antimicrobial treatment choice.
Conclusion: A higher degree of irrational use of antimicrobial agents occurs in the ICU of the hospital
studied, this can lead to increase in the burden of disease.
Rational use; Antimicrobial; Empirical treatment; Gyssens method; Intensive care
Alternative site location: http://www.tjpr.org