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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-5996
Vol. 14, No. 5, 2015, pp. 753-760
Bioline Code: pr15098
Full paper language: English
Document type: Editorial
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 14, No. 5, 2015, pp. 753-760

 en Formulation and Characterization of Biodegradable Medicated Chewing Gum Delivery System for Motion Sickness using Corn Zein as Gum Former
Mehta, Farhad Firoze & Trivedi, Piyush


Purpose: To formulate and evaluate biodegradable corn zein as a base for diphenhydramine hydrochloride medicated chewing gum for effective management of motion sickness.
Method: Corn zein gum formulations were prepared using a fixed concentration (35 % w/w) of different plasticizer for each formulation. Substances used as plasticizer were triacetin, oleic acid, polyethylene glycol (PEG)-600, tributyl citrate, PEG-200, PEG-300, PEG-400, PEG-4000, triethyl citrate and castor oil. The gum formulations were characterized for the following parameters: texture profile analysis (TPA), biodegradation, in vitro drug release using a modified chewing apparatus, and sensory properties.
Result: Formulations code MCG-5 and MCG-9 which incorporated glyceryl triacetate and castor oil as plasticizers, respectively, showed a biodegradation score of 2 and 1, respectively, indicating significant biodegradation. The formulation with castor oil as plasticizer showed hardness, gumminess, chewiness, and cohesiveness of 4228.87 g, 1002.52, 360.06 g and 0.237; these values are similar to that of the reference, Superpep® travel chewing gum. In vitro drug release of the drug was 95 %, and showed uniform distribution of the drug in the gum matrix.
Conclusion: Corn zein is suitable for use as a biodegradable gum base for the delivery of diphenhydramine hydrochloride, and can be developed as an alternative to currently used gum bases for commercial products.

Corn zein; Chewing gum delivery system; Motion sickness; Biodegradation; Texture profile analysis; Sensory evaluation

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