Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 14, No. 5, 2015, pp. 777-782
Bioline Code: pr15101
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 14, No. 5, 2015, pp. 777-782
© Copyright 2015 - Tropical Journal of Pharmaceutical Research
Cytotoxic Effect of Turkish Propolis on Liver, Colon, Breast, Cervix and Prostate Cancer Cell Lines|
Turan, Ibrahim; Demir, Selim; Misir, Sema; Kilinc, Kagan; Mentese, Ahmet; Aliyazicioglu, Yuksel & Deger, Orhan
Purpose: To investigate the total polyphenolic and flavonoid contents, antioxidant power and cytotoxic
activity of ethanol extracts of Turkish propolis (EEP).
Methods: The total polyphenolic and flavonoid contents of EEP were determined by spectrometric
methods. Antioxidant power and cytotoxic activity of EEP were evaluated using ferric reducing
antioxidant power (FRAP) and MTT assays, respectively.
Results: The total polyphenolic and flavonoid contents, and FRAP value of EEP were 124.6 ± 1.5 mg
gallic acid/g sample dry weight , 42.0 ± 0.8 mg quercetin/g sample dry weight and 311.0 ± 2.5 mg
trolox/g sample dry weight, respectively. EEP exhibited powerful cytotoxic effects against the five
human cancer cell lines. The highest cytotoxic activity of Turkish EEP was demonstrated on PC-3 cell
line (IC50 = 20.7±3.4 μg/mL).
Conclusion: The results demonstrate that EEP is a good source of antioxidant and a natural antitumor
agent capable of reducing cancer cell proliferation.
Propolis; Polyphenols; Cytotoxic effect; Cancer cell lines; Antioxidant activity
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