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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 14, No. 6, 2015, pp. 935-940
Bioline Code: pr15122
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 14, No. 6, 2015, pp. 935-940

 en Floating Microparticulate Oral Diltiazem Hydrochloride Delivery System for Improved Delivery to Heart
Cheng, Hai - feng; Feng, Yan; Duan, Qun - jun; Jiang, Da - Ming & Tao, Kai - Yu

Abstract

Purpose: To formulate and evaluate floating microparticulate oral diltiazem delivery system for possible delivery to the heart .
Method: Floating microspheres w ere prepared using cellulose acetate and Eudragit RS100 polymers by emulsion solvent evaporation technique. The dried floating microspheres were evaluated for micromeritic properties (flow properties, density, particle size determination) scanning as well as by electron microscopy, and in vitro floatability and drug release studies.
Results: The microspheres showed good buoyancy, good flow properties (angle of repose ranging from 24.29 to 29.02 º), particle size (262.09 to 409.60 μm) and good drug loading (74.29 to 92.09 %). The microspheres were porous, hollow and spherical. All the formulations showed good in vitro controlled drug release in the range of 77.62 ± 2.12 to 97.50 ± 1.04 % at the end of 12 h. Drug release was diffusion - controlled and followed zero order kinetics.
Conclusion: Microparticulate floating (gastroretentive) oral drug delivery system of diltiazem prepared using cellulose acetate and Eudragit R5100 may be an effective alternative to conventional oral tabl ets for cardiac drug delivery.

Keywords
Cardiac; Microparticulate; Drug release; Gastroretentive; Floating microspheres; Diltiazem hydrochloride

 
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