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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 14, No. 6, 2015, pp. 1029-1034
Bioline Code: pr15134
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 14, No. 6, 2015, pp. 1029-1034

 en Phytochemical Screening and Hepatoprotective Effect of Alhagi maurorum check for this species in other resources Boiss (Leguminosae) Against Paracetamol - Induced Hepatotoxicity in Rabbits
Rehman, Jalil Ur; Akhta, Naveed; Khan, Muhammad Younus; Ahmad, Khalil; Ahmad, Mukhtiar; Sultana, Sabira & Asif, Hafiz Muhammad

Abstract

Purpose: To evaluate the hepatoprotective activity of aqueous - ethanol (30:70 %) extract of Alhagi maurorum check for this species in other resources Boiss. (Leguminosae) whole plant against paracetamol-induced liver injury in experimental rabbits.
Methods: Aqueous-ethanol extract of Alhagi maurorum at doses of 250 mg/kg and 500 mg/kg body weight, p.o., was administered for 7 days in paracetamol (2 gm/kg, s.c.) intoxicated rabbits and compared with silymarine (50 mg/kg, p.o.)-treated rabbits. Biochemical parameters, alkaline phosphatase (ALP), serum glutamic oxalacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT) and total bilirubin (TB) levels were recorded to investigate the degree of improvement in the conditions of the rabbits. The liver was removed, washed with normal saline and preserved in 10 % formalin and used in histopathological studies of hepatic architecture by microscopy. Phytochemical screening of the extract was also carried out.
Results: The levels of biochemical parameters were increased in paracetamol intoxicated rabbits when compared with the normal group. The extract, at doses of 250 and 500 mg/kg, exhibited significant (p<0.001) reduction in biochemical parameters (ALP, SGOT, SGPT and TB). Hepatoprotective activity was also confirmed by histopathological findings. Furthermore, the phytochemical profile of the extract revealed the presence of tannins, alkaloids, saponins and flavonoids.
Conclusion: These results suggest that Alhagi maurorum extract possesses significant hepatoprotective effect against paracetamol-induced hepatotoxicity and this may be due to the presence of flavonoids and tannins.

Keywords
Alhagi maurorum; Hepatoprotective; Paracetamol; Silymarin; Histopathology

 
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