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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-5996
Vol. 14, No. 6, 2015, pp. 1057-1062
Bioline Code: pr15138
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 14, No. 6, 2015, pp. 1057-1062

 en Ameliorative Effect of Lecaniodiscus cupanioides check for this species in other resources (Sapindaceae) Aqueous Root Extract in Loperamide - Induced Constipated Rats
Nafiu, Mikhail O.; Abdulsalam, Taoheed A.; Jimoh, Rukayat O. & Kazeem, Mutiu I.

Abstract

Purpose: To evaluate the efficacy of aqueous root extract of Lecaniodiscus cupanioides check for this species in other resources Planch. (Sapindaceae) against loperamide - induced constipation in Wistar rats.
Methods: Constipation was induced by oral administration of loperamide (3 mg/kg body weight). The constipated rats were orally treated daily either with 50, 150, 250 mg/kg body weight per day of th e extract or 0.21 mg /kg bisacodyl (reference drug) for 7 days while the normal control group received distilled water. The feeding characteristics, body weight, faecal properties and gastrointestinal tr ansit ratio were monitored throughout the study period. The activities of acid phosphatase (ACP), alkaline phosphatase (ALP), aspartate aminotransferase (AST), γ - glutaryltransferase (GGT) and lactate dehydrogenase (LDH) were also determined in the serum of the animals.
Results: There was significant decrease (p < 0.05) between n ormal and constipated rats in the number of faecal pellets (54.06 and 45.43) while body weight increased (124.45 and 135.38 g) respectively. Administration of 250 mg/kg L. cupanioides extract to the constipated rats significantly normalized (p < 0.05) their body weight gain (8.15 g) and gastrointestinal ratio (87.75) compared to the constipated control. Serum levels of ACP and AST were significantly elevated (p < 0.05) in the 150 and 250 mg/kg dose groups compared to controls while ALP witnessed reduction. However, there was no alteration in the levels of GGT and LDH across all groups.
Conclusion: The aqueous root extract of L. cupanioides possesses laxative activity in loperamide - induced constipated rats.

Keywords
Constipation; Lecaniodiscus cupanioides; Gastrointestinal transit ratio; Loperamide; Bisacodyl

 
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