Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 14, No. 6, 2015, pp. 1071-1074
Bioline Code: pr15140
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 14, No. 6, 2015, pp. 1071-1074
© Copyright 2015 - Tropical Journal of Pharmaceutical Research
Effect of Oral Vitamin E on Serum Lipid Profile of Apparently Healthy Nigerians in Benin City|
Okosun, Romanus E. & Adu, Matthew E.
To investigate the effect of oral vitamin E on serum lipid profile of Apparently Healthy Nigerians in Benin City
Fifty eight apparently healthy non-smoking males aged 30 -59 years were randomly selected
from Benin metropolis and were divided in three groups. The effect of oral vitamin E (a potent antioxidant) supplementation in various dosages 100 mg/day, 200 mg/day and 400 mg/day for 21 days
on Total cholesterol, Triglycerides, High Density Lipoprotein, Low Density Lipoprotein and Very low
Density Lipoprotein was examined.
The serum total cholesterol, triglycerides, low density lipoprotein and very low density
lipoprotein of the subjects showed a decrease which was not statistically significant (p > 0.05) after treatment with various doses of oral vitamin E.
The effect of oral vitamin E on blood lipids is not significant when administered alone to
healthy male subjects. This may be due to the function of α-tocopherol (vitamin E) as a pro-oxidant in the formation of lipid radical via α-tocopherol mediated pathway.
Atherosclerosis; Pro - oxidant; Vitamin E; Antioxidants; Lipid profile; Dyslipidaemia
Alternative site location: http://www.tjpr.org