Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 14, No. 7, 2015, pp. 1129-1135
Bioline Code: pr15148
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 14, No. 7, 2015, pp. 1129-1135
© Copyright 2015 - Tropical Journal of Pharmaceutical Research
Drug Release Mechanism of Slightly Soluble Drug from Nanocomposite Matrix Formulated with Zeolite/ Hydrotalcite as Drug Carrier|
Ainurofiq, Ahmad & Choiri, Syaiful
Purpose: To evaluate the mechanism of drug release of a slightly soluble drug (theophylline) from
nanocomposite of zeolite (ZLT) or hydrotalcite (HTC) used as drug carrier.
Methods: Nanocomposite was prepared with dispersion of either ZLT or HTC as drug carrier and
theophylline (THP) as drug in drug to clay ratios of 1:2, 3:4 and 1:1. The formulations were
characterized for drug release and loading. Dependent and independent kinetic models were employed
to analyze the drug release data. Fourier transform infrared spectroscopy (FTIR) was used for the
structural characterization of the formulations.
Results: Nanocomposite was formed due to incorporation of the drug in the basal spacing of ZLT/HTC.
The drug loading of THP/ZLT and THP/HTC composites were 38.10 % for 2 h and 27.35 % for 3 h,
respectively. HTC and ZLT nanocomposite retarded drug release for 6 h. Non-linear and Peppas-Sahlin
were the best fitting kinetic release models based on the goodness of fit.
Conclusion: ZLT provides better drug loading capacity than HTC. However, both ZLT and HTC are
suitable for the formulation of controlled release products. The drug release kinetics and mechanism
were a combination of Fickian and non-Fickian diffusion.
Zeolite; Hydrotalcite; Clays; Nanocomposite; Theophylline; Drug release kinetics; Basal spacing
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