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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 14, No. 7, 2015, pp. 1207-1212
Bioline Code: pr15158
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 14, No. 7, 2015, pp. 1207-1212

 en Chemical Composition and Antifungal Properties of Essential Oil of Origanum vulgare check for this species in other resources Linnaeus (Lamiaceae) against Sporothrix schenckii check for this species in other resources and Sporothrix brasiliensis check for this species in other resources
Couto, Camila S.F.; Raposo, Nádia R.B.; Rozental, Sônia; Borba-Santos, Luana P.; Bezerra, Leila M.L.; de Almeida, Priscila A. & Brandão, Marcos A.F.

Abstract

Purpose: To evaluate the effect of the essential oil of Origanum vulgare check for this species in other resources Linnaeus (Lamiaceae) on the growth of Sporothrix schenckii check for this species in other resources and Sporothrix brasiliensis check for this species in other resources .
Methods: The chemical composition of the essential oil was investigated by gas chromatography/flame ionization detector (GC-FID). The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were determined by broth micro-dilution method. Scanning electron microscopy (SEM) was also performed to reveal morphological alterations in Sporothrix check for this species in other resources spp. cells.
Results: The major components of the essential oil were γ-terpinene (30.5 %), carvacrol (15.7 %) and 4-terpineol (13.0 %). γ-Terpinene showed potential antifungal activity with MIC ranging from 62.5 to 500.0 μg mL-1 for S. schenckii, and 125.0 to 250.0 μg mL-1 for S. brasiliensis. SEM micrographs revealed morphological alterations in hyphae and reduction of the adhered conidia numbers.
Conclusion: Origanum vulgare Linnaeus essential oil possesses potential antifungal activity, and can, therefore, can be developed as an alternative agent for the treatment of sporotrichosis.

Keywords
Antifungal activity; Essential oil; Gas chromatography; Origanum vulgare; Sporotrichosis

 
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