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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 14, No. 7, 2015, pp. 1213-1216
Bioline Code: pr15159
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 14, No. 7, 2015, pp. 1213-1216

 en Effect of Carthamus tinctorius check for this species in other resources L Extract on Diethylnitrosamine-Induced Liver Cirrhosis in Rats
Hu, Zhi-wei & Wang, Wei-xing


Purpose: To explore the effects of Carthamus tinctorius check for this species in other resources L. extract (CTLE) on diethylnitrosamine (DEN)- induced liver cirrhosis in rats.
Methods: CTLE was obtained by extracting the dried Carthamus tinctorius L. in water. Liver cirrhosis was induced by injecting the rats with DEN once a week for 8 weeks. Following this treatment, clinical biochemical assessments, as well as oxidative stress test and histopathological examination were performed.
Results: Compared with the control group, plasma concentrations of alanine transaminase (ALT) and aspartate aminotransferase (AST) both decreased significantly (p < 0.01) after 8 weeks. The degree of liver fibrosis, cirrhosis and necrosis decreased in CTLE-treated rats. CTLE significantly inhibited malondialdehyde (MDA) and superoxide dismutases (SOD) in DEN-induced rat liver (p < 0.01) compared with control group.
Conclusion: CTLE has significant inhibitory effect on diethylnitrosamine-induced liver cirrhosis in rats, which can be developed for future clinical applications.

Carthamus tinctorius L.; Liver cirrhosis; Anti-oxidant; Apoptosis; Diethylnitrosamine

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