Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 14, No. 7, 2015, pp. 1285-1291
Bioline Code: pr15169
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 14, No. 7, 2015, pp. 1285-1291
© Copyright 2015 - Tropical Journal of Pharmaceutical Research
Association between Oral Anticoagulation Knowledge, Anticoagulation Control, and Demographic Characteristics of Patients Attending an Anticoagulation Clinic in Saudi Arabia: A Cross-Sectional Prospective Evaluation|
Mayet, Ahmed Y.
Purpose: To assess the level of knowledge on warfarin therapy and anticoagulation control, and
explore the association between knowledge and anticoagulation control in a section of Saudi population.
Methods: A cross-sectional prospective survey was conducted over a 4-week period in 2013 at King
Khalid University Hospital outpatient anticoagulant clinic in Riyadh, Saudi Arabia. Adult patients who
were either discharged on warfarin or taking warfarin and attending the outpatient anticoagulant clinic
for . 6 months were invited to participate in the study. A questionnaire was used to collect the
demographic data and knowledge of warfarin therapy (8-item). International Normalized Ratio (INR)
readings were obtained from electronic-laboratory database. Good knowledge of warfarin was defined
as a score of ≥ 75 % and good (INR) control was defined as . 75 % Time INR in therapeutic range
(TTR) calculated using Rosendaal method.
Results: A total of 105 patients completed the questionnaire with a response rate of 49.2 %. Seventynine
patients (75.2 %) had good knowledge of warfarin (scored ≥ 75 %), but only 35 patients (33.3 %)
had good anticoagulation control (TTR ≥ 75 %). An association was observed between patients with no
formal education and poor warfarin knowledge (p = 0.012). Smoking history was also linked with
warfarin knowledge (p = 0.025). INR control results significantly differed by marital status with
divorced/widow status displaying poor INR control (p = 0.028). Lastly, no association was found
between good knowledge and good INR control (OR 1.35, 95 %; CI 0.537 – 3.392).
Conclusions: The majority of patients seen at the outpatient anticoagulation clinic have good
knowledge of warfarin therapy although only a third showed good anticoagulation control. The results
indicate no significant association between knowledge of warfarin therapy and anticoagulation control.
Studies with a larger sample size are recommended to verify the foregoing results.
Oral anticoagulant; Warfarin; International normalized ratio; Knowledge; Anticoagulation control
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