Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 14, No. 7, 2015, pp. 1293-1298
Bioline Code: pr15170
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 14, No. 7, 2015, pp. 1293-1298
© Copyright 2015 - Tropical Journal of Pharmaceutical Research
Evaluation of Therapeutic Effects of Radiotherapy during Treatment of Lung Adenocarcinoma in Mice with Positron Emission Tomography Imaging of 18F-FLT and 18F-FDG|
Qu, Baolin; Wang, Hui; Yu, Wei; Zhang, Jinming; Zhang, Huijuan & Tian, Jiahe
Purpose: To assess the role of 3'-deoxy-3'-18F-fluoro-thymidine (18F-FLT) and 2'-deoxy-2'-18F-fluorodeoxy-
glucose (18F-FDG) positron emission tomography (PET) imaging in the evaluation of the
therapeutic effects of radiotherapy during treatment of lung adenocarcinoma.
Methods: Eighteen mice with lung adenocarcinoma were randomly divided into 2 groups; each group
was randomly paired and evenly divided into three smaller groups, namely, A, B and C. Group A served
as the control group without any treatment; mice in group B were received radiotherapy in sites of
tumor. A single dose of 2000 cGy, 6MV x-ray was used in this experiment; mice in group C also
received radiotherapy at sites of tumors two days before the experiment using the same procedure and
dose as group B. Micro PET imaging was taken after intravenous injection of 18F-FLT and 18F-FDG
through the mice’s tail.
Results: The intake ratio of 18F-FLT and 18F-FDG was much higher at the tumor sites. After
radiotherapy, 18F-FLT uptake was significantly lower than that of the control group (p < 0.05), while
there was no obvious change of 18F-FDG uptake. There was a significant decrease in T/NT value of FLT
PET imaging group 24 and 48 h after radiotherapy; a significant difference could be seen, compared
with that before radiotherapy (p < 0.05).
Conclusion: Change in 18F-FLT uptake induced by radiotherapy is more sensitive than that of 18F-FDG.
Intake of 18F-FLT is lowered more significantly after radiotherapy than that of 18F-FDG, and this can
serve as evidence that 18F-FLT is an effective tracer to monitor the therapeutic effect of radiotherapy on
3'-deoxy-3'-18F-fluoro-thymidine; 2'-deoxy-2'-18F-fluoro-deoxy-glucose; Radiotherapy; Positron Emission Tomography imaging; Cell proliferation; Lung adenocarcinoma
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