Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 14, No. 8, 2015, pp. 1469-1473
Bioline Code: pr15192
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 14, No. 8, 2015, pp. 1469-1473
© Copyright 2015 - Tropical Journal of Pharmaceutical Research
Effect of Ankaferd Blood Stopper on Early Bone Tissue Healing in Extraction Sockets: An Experimental In vivo Study|
Yuce, Hatice Balci; Akbulut, Nihat; Akbulut, Sibel; Demiralp, Kemal Özgür; Karaca, Zafer & Orhan, Kaan
To investigate the effect of Ankaferd blood stopper (ABS) on early bone healing of extraction
sockets in rats.
Twenty-eight male Wistar rats were divided into four groups. The maxillary right first molar
tooth of the rats was extracted under general anesthesia. Two groups (C−1, n =6 and C−2, n =6)
received saline solutions in the extraction sockets immediately and one day after the extraction,
respectively, while two groups (A−1, n = 8 and A−2, n = 8) received ABS. The rats in A−1 and C−1 groups
were sacrificed after 7 days of post-extraction while the rats in A−2 and C−2 groups were sacrificed after
28 days. Bone samples were taken from the maxillas, and tissues were prepared for histopathological
analysis. Osteoid tissue (OT), mineralized bone tissue (MT), remaining area (RA), and inflammatory cell
infiltration (ICI) were determined. The histomorphometric results were analyzed statistically using
analysis of variance (ANOVA).
Osteoid formation was highest in C−1 group (39.71 ± 9.68, p < 0.05). Differences in OT among
other groups were not significant (p > 0.05). MT was higher in C−2 group (47.73 ± 12.15) than in other
groups (p < 0.05). RA was highest in C−1 group (59.95 ± 12.75). ICI was significantly lower in control
(C1 and C−2) groups than in ABS (A−1 and A−2) groups (p < 0.05).
ABS administered topically to extraction sockets immediately after extraction has no effect
on bone healing; in fact, ABS increases inflammation in vivo.
Ankaferd blood stopper; Wound healing; Mineralized bone tissue; Inflammatory cell infiltration; Osteoid tissue; Tooth extraction
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