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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 14, No. 8, 2015, pp. 1495-1499
Bioline Code: pr15196
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 14, No. 8, 2015, pp. 1495-1499

 en Prevalence of Methicillin-Resistant Staphylococcus aureus check for this species in other resources among Healthy Residents of Ekosodin Community in Benin-City, Nigeria
Akerele, J. O.; Obasuyi, O. & Omede, D.

Abstract

Purpose: To determine the prevalence of methicillin-resistant Staphylococcus aureus check for this species in other resources (MRSA) in apparently healthy residents of Ekosodin community, a peri-urban settlement, in Benin City, Nigeria.
Method: Nasal swabs collected from 200 randomly selected individuals, aged between 16 and 38 years, were used in the study. Isolates from the swabs were aseptically collected and characterized using standard and established microbiological methods, which included growth and fermentation on mannitol salt agar (MSA), colonial morphology, Gram-staining reaction and biochemical tests. Antimicrobial susceptibility test was performed on Mueller-Hinton agar (MHA) by modified Kirby-Bauer disc diffusion method.
Results: S. aureus was isolated in 49.5 % (n = 99) of the 200 nasal swabs. Among these isolates, 43 % were from male residents and 22.2 % (n = 22) were MRSA. The MRSA isolates indicated relatively high rate of resistance to penicillins, moderate resistance to erythromycin and cefuroxime, and least resistance to gentamicin, streptomycin, ceftriaxone, ciprofloxacin and co-trimoxazole. There was no significant gender difference in terms of the colonization of S. aureus (p < 0.05).
Conclusion: Many apparently healthy residents of Ekosodin community are nasal carriers of MSRA. The need for rational chemotherapy, routine detection and regular surveillance of MRSA to limit its spread and reduce treatment failures is vital.

Keywords
Methicillin-resistant Staphylococcus aureus; Nasal swabs; Multidrug resistance; Rational chemotherapy; Treatment failure; Peri-urban community

 
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