Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 14, No. 9, 2015, pp. 1541-1547
Bioline Code: pr15201
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 14, No. 9, 2015, pp. 1541-1547
© Copyright 2015 - Tropical Journal of Pharmaceutical Research
Preparation and Characterization of Colon-Specific Microspheres of Diclofenac for Colorectal Cancer|
Dang, Tong; Cui, Ying; Chen, Yan-Dong; Meng, Xian-Mei; Tang, Bo-Fu & Wu, Jin-Bao
Purpose: To prepare and evaluate colon specific drug delivery system of diclofenac sodium for highly
localized delivery to the colon.
Methods: The colon specific drug delivery system was prepared as matrix-type microspheres using
Ethyl Cellulose (EC), Cellulose Acetate Phthalate (CAP), and Eudragit L 100-55 by the Solvent
Evaporation Method. Microspheres were evaluated for physical properties like drug content, particle
size, bulk density and angle of repose.
Results: The size range of the microcapsules was 228 to 608 μm while drug content was between
74.49 and 91.50 % depending on the polymer used and the polymer ratio. Mean bulk density was < 1.2
g/ml which indicates the good flow properties, while angle of repose was < 40 °, indicating free-flowing
properties. The microspheres were spherical in shape with smooth and nonporous surface, except that
the microspheres containing EC and CAP exhibited a rough and porous surface. The microspheres
containing Eudragit L 100-55 in combination with other polymers gave better sustained release (78.9
and 76.6 % at the end of 8 h for formulation F4 and F5, respectively) than the others.
Conclusion: Microspheres prepared with drug: EC: CAP ratio of 1:2:1 show the highest drug content,
possess good flow properties and surface morphology, as well as promising drug release for colon
specific drug delivery of diclofenac sodium for possible treatment of colorectal cancer.
Diclofenac; Colorectal cancer; Microspheres; Ethyl cellulose; Cellulose acetate phthalate; Eudragit L 100-55
Alternative site location: http://www.tjpr.org