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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 14, No. 9, 2015, pp. 1565-1571
Bioline Code: pr15204
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 14, No. 9, 2015, pp. 1565-1571

 en Preparation and Characterization of a Complex of Paeonol and Hydroxypropyl-β-cyclodextrin
Chen, Chungang; Xu, Xinjuan; Li, Yaoran & Ma, Hanjun

Abstract

Purpose: To improve the solubility of paeonol in water by complexing with hydroxypropyl-β-cyclodextrin (HP-β-CD) and also to characterize the physicochemical properties of the complex.
Methods: The complex of paeonol and HP-β-CD was prepared by freeze-drying method. Its physicochemical properties were studied by phase-solubility method, ultraviolet-visible spectrometry (UV), infrared spectrometry (IR), scanning electron microscopy (SEM), x-ray diffractometry (XRD) and thermogravimetric/differential scanning calorimetry (TG/DSC).
Results: The phase-solubility results showed that paeonol formed a 1:1 stoichiometric complex with HP-β-CD while UV and IR spectra suggested that HP-β-CD and paeonol in the complex interacted by a non-covalent bond. SEM and XRD indicate that the heat stability of paeonol was significantly improved by complexing with HP-β-CD.
Conclusion: Paeonol can be efficiently complexed with HP-β-CD to form a complex by freeze-drying method. The aqueous solubility and heat stability of paeonol is significantly improved by complexation HP-β-CD.

Keywords
Paeonol; Hydroxypropyl-β-cyclodextrin; Complexation; Aqueous solubility; Heat stability

 
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