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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-5996
Vol. 14, No. 9, 2015, pp. 1613-1619
Bioline Code: pr15210
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 14, No. 9, 2015, pp. 1613-1619

 en Impact of Co-administration of Red Palm Oil ( Elaeis guineensis check for this species in other resources Arecaceae) and Rooibos ( Aspalathus linearis check for this species in other resources Fabaceae) on Glycaemic Parameters, Liver Function and Key Glycolytic Enzymes in Diabetic Rats
Ayeleso, Ademola O.; Oguntibeju, Oluwafemi O. & Brooks, Nicole L.


Purpose: To investigate the anti-diabetic effects of red palm oil (RPO), rooibos tea extract (RTE) and their combination (RPO + RTE).
Methods: Diabetes was induced by a single administration of streptozotocin (50 mg/kg) and the rats were treated for 49 days. The effects of these plant products on plasma glucose, serum insulin, serum fructosamine, glycosylated haemoglobin (HbIAC), liver enzymes in serum and liver glycolytic enzymes were studied using standard techniques.
Results: The combined treatment of RPO and RTE significantly (p < 0.05) decreased the glucose (20.98 ± 6.46 mmol/L to 15.60 ± 5.94 mmol/L), HbIAC (16.74 ± 2.73 % to 12.41 ± 2.25 %), fructosamine (98.61 ± 23.35 mmol/L to 62.52 ± 28.41 mmol/L) levels and increased insulin (0.30 ± 0.09 ng/mL to 0.72 ± 0.21 ng/mL) levels in the diabetic rats. Similarly, the combined treatment significantly (p < 0.05) reduced alanine aminotransferase (ALT) in the serum of diabetic rats. RPO + RTE significantly (p < 0.05) increased the activity of pyruvate kinase in the liver when compared with the diabetic control group.
Conclusion: Combined treatment with red palm oil and rooibos shows promising beneficial effects in diabetic conditions of rats. Further studies on the mechanism of actions of the plant products are required.

Red palm oil; Rooibos; Glycaemic parameters; Liver function; Glycolytic enzymes; Diabetic rats

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