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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 14, No. 10, 2015, pp. 1829-1835
Bioline Code: pr15238
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 14, No. 10, 2015, pp. 1829-1835

 en Potential Anticonvulsant Activity of Ethanol Extracts of Cichorium intybus check for this species in other resources and Taraxacum serotinum check for this species in other resources in Rats
Abdel-Rahman, Rehab F.; Soliman, Gamal A.; Yusufoglu, Hasan S.; TatliÇankay, Irem; Alqasoumi, Saleh I.; Anul, Serap Arabci & Akaydin, Galip

Abstract

Purpose: To evaluate the acticonvulsant activity of Cichorium intybus check for this species in other resources (C. intybus) and Taraxacum serotinum check for this species in other resources (T. serotinum) in maximal electroshock (MES), as well as pentylenetetrazole (PTZ)- and strychnine nitrate (STN) - induced seizure models in rats.
Methods: For each model, 8 groups of Swiss albino rats (n=10) were used. The 1st group was kept as control, 2nd as standard (diazepam, 7.5 mg/kg); 3rd - 5th were treated with C. intybus ethanol extract (125, 250 and 500 mg/kg); and 6th - 8th treated with T. serotinum extract (125, 250 and 500 mg/kg). After 30 min of administration, the rats were exposed to a shock of 150 mA by a convulsiometer, via ear electrodes for 2 s (in MES test) or sc injection of PTZ (85 mg/kg) or STN (2.5 mg/kg). Anticonvulsant activity was confirmed by abolition of hind limb tonic extension (HLTE) in MES test and by measuring the latency to PTZ or STN-induced threshold seizures, and the duration of seizures in the rats.
Results: In MES model, 500 mg/kg of C. intybus and T. serotinum resulted in complete abolition of HLTE in 70 and 50 % of the rats, respectively, compared to 80 % in diazepam-medicated animals. Both extracts at 500 mg/kg prolonged latency to seizure onset in PTZ model to 144.7 and 114.7 s, respectively (vs 55.2 s in control group; p < 0.05). Both extracts failed to protect rats against STNinduced seizures.
Conclusion: C. intybus and T. serotinum possess anticonvulsant effect as they both abolish HLTE induced by MES and delay the latency of seizures produced by PTZ.

Keywords
Cichorium intybus; Taraxacum serotinum; Anticonvulsant; Seizures; Maximal electroshock; Pentylenetetrazole; Strychnine nitrate

 
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