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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 14, No. 11, 2015, pp. 1999-2004
Bioline Code: pr15261
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 14, No. 11, 2015, pp. 1999-2004

 en Effect of Alcohol Extract of Zataria multiflora (Boiss), Satureja bachtiarica check for this species in other resources (Bunge) and Zaravschanica membranacea (Boiss) on Immuno-Hematologic Factors in Rats
Dehkordi, Hamed Soleyman; Dehkordi, Mohsen Jafarian; Chaleshtori, Milad Rezamand; Khamesipour, Faham & Katsande, Simbarashe

Abstract

Purpose: To determine the effect alcohol extract of Zataria multiflora, Satureja bachtiarica check for this species in other resources and Zaravschanica membranacea on immunohematologic factors in Wistar rats.
Methods: Wistar rats were randomly allocated to seven treatment groups which consisted of control group with water and feed only (1); 200 mg. kg-1 Z. membranacea (2); 400 mg. kg-1 Z. membranacea (3); 200 mg. kg-1 S. bachtiarica (4); 400 mg. kg-1 S. bachtiarica (5); 200 mg. kg-1 Z. multiflora (6) and 400 mg. kg-1 Z. multiflora (7). Erythrocyte counts (RBC), packed cell volumes (PCV), haemoglobin (Hb) concentration, mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), Translocation and Assembly Module (Tam) protein, IgM and albumin were measured after 29 days.
Results: Z. membranacea at 200 mg kg-1 showed the highest level of Tam-protein content (p < 0.05). Z. multiflora boiss at 400 mg kg-1 produced higher levels of immunoglobulin M (IgM) compared to S. bachtiarica and Z. multiflora (p < 0.05). Both Z. membranacea and S. bachtiarica at 200 mg. kg-1 caused a significant increase in albumin levels in the rats (p < 0.05). Z. multiflora at 400 mg. kg-1 had the highest effect on white blood cells (WBC) while S. bachtiarica produced the highest effect on neutrophils (Nut) (p < 0.05). Z. membranacea and Z. multiflora at 200 mg. kg-1 showed significantly higher levels of monocytes (Mon) % (p < 0.05). Z. multiflora and S. bachtiarica at 400 mg. kg-1 showed a significant effect on phagocytosis % (p < 0.05) whilst S. bachtiarica at 400 mg.kg-1 had a significant effect on phagocytosis number (p < 0.05).
Conclusion: The alcohol extracts of Z. multiflora Z. membranacea and S. bachtiarica extracts are capable of stimulating the immune defense mechanism without causing undesirable effects on hematological parameters.

Keywords
Zataria multiflora; Satureja bachtiarica; Zaravschanica membranacea; Immunoglobulin; Serum albumen; Immunohematologic factors

 
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