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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 14, No. 11, 2015, pp. 2005-2008
Bioline Code: pr15262
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 14, No. 11, 2015, pp. 2005-2008

 en Acetyl-cholinesterase Enzyme Inhibitory Effect of Calophyllum check for this species in other resources species
Ee, Gwendoline Cheng Lian; Teh, Soek Sin; Mah, Siau Hui; Ain Jamaluddin, Nur; bin Muhamad Sahimi, Muhamad Syarik & Ahmad, Zuraini

Abstract

Purpose: To search for new acetylcholinesterase enzyme inhibitors from Calophyllum check for this species in other resources species.
Methods: Six stem bark extracts of Calophyllum inophyllum check for this species in other resources , C. soulattri check for this species in other resources , C. teysmannii check for this species in other resources , C. lowii check for this species in other resources , C. benjaminum check for this species in other resources and C. javanicum check for this species in other resources were subjected to anti-cholinesterase analysis against acetylcholinesterase (AChE) enzyme using Ellman’s method.
Results: Most of the extracts showed promising inhibitory activity against AChE at concentrations of 100 μg/mL, with the methanol extract of C. inophyllum demonstrating the strongest inhibitory effect of 81.28 % followed by the methanol extract of C. benjaminum with 74.32 % inhibition. The methanol extracts of Calophyllum inophyllum and Calophyllum bejaminum also showed significant inhibitory activity towards the acetylcholinesterase (AChE) enzyme.
Conclusion: Calophyllum species is capable of yielding potential lead compounds for the development for acetyl-cholinesterase enzyme inhibition drugs.

Keywords
Calophyllum species; Acetylcholinesterase; Inhibitors

 
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