Purpose: To search for new acetylcholinesterase enzyme inhibitors from
Calophyllum
species.
Methods: Six stem bark extracts of
Calophyllum inophyllum
,
C. soulattri
,
C. teysmannii
,
C. lowii
,
C. benjaminum
and
C. javanicum
were subjected to anti-cholinesterase analysis against
acetylcholinesterase (AChE) enzyme using Ellman’s method.
Results: Most of the extracts showed promising inhibitory activity against AChE at concentrations of
100 μg/mL, with the methanol extract of
C. inophyllum demonstrating the strongest inhibitory effect of
81.28 % followed by the methanol extract of
C. benjaminum with 74.32 % inhibition. The methanol
extracts of
Calophyllum inophyllum and
Calophyllum bejaminum also showed significant inhibitory
activity towards the acetylcholinesterase (AChE) enzyme.
Conclusion: Calophyllum species is capable of yielding potential lead compounds for the development
for acetyl-cholinesterase enzyme inhibition drugs.
