Purpose: To elucidate the solid-state conformation as well as the imine double bond configuration of a
potential anti-
Candida
agent ({[(1
E)-3-(1
H-imidazol-1-yl)-1-phenylpropylidene]amino}oxy)(3,4,5-
trimethoxyphenyl)methanone.
Methods: Acetophenone was used as a starting material to prepare the target oximino ester in a fourstep
reaction sequence. Nuclear magnetic resonance (
1H-NMR and
13C-NMR) and mass spectrometry
were used to confirm the chemical structure of the synthesized compounds. Thereafter, x-ray
crystallography was performed on single crystals of the target compound. The solid-state conformation
of the target molecule and the (E)-configuration of its imine double bond were determined via the
investigation of its single crystal x-ray molecular structure.
Results: The titled compound crystallized in the triclinic space group P-1 with a = 11.0719 (7) Å, b =
14.6602 (9) Å, c = 14.8530 (9) Å, α = 67.205 (4)°, β = 80.388 (5)º, γ = 70.100 (5)°, V = 2088.2 (2) Å
3,
and Z = 4. Individual molecules were packed in the crystal by three weak non-classical intermolecular
hydrogen interactions, including C9A—H9AA•••O3A, C9B—H9BA•••O3B, C18B—H18C•••O2A and
C20B—H20B•••O4B.
Conclusion: The results of the single crystal x-ray molecular structure of the titled anti-
Candida agent
unequivocally confirmed its (E)-configuration.
