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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 14, No. 11, 2015, pp. 2083-2089
Bioline Code: pr15273
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 14, No. 11, 2015, pp. 2083-2089

 en In vitro Antifungal Activity of Baccharis trimera check for this species in other resources Less (DC) Essential Oil against Dermatophytes
Caneschi, C. A.; Martins, F. J.; Larrudé, D. G.; Romani, E. C.; Brandão, M. A. F. & Raposo, N. R. B.

Abstract

Purpose: To identify the main components of the essential oil (EO) of Baccharis trimera check for this species in other resources Less and investigate their in vitro antifungal activity against seven fungal strains that cause onychomycosis.
Methods: The chemical composition of EO was determined using gas chromatography, and its minimum inhibitory concentration (MIC), minimum fungicidal concentration (MFC), and antifungal activity were compared with those of terbinafine and ketoconazole. Scanning electron microscopy (SEM) was used to investigate morphological changes in the strains of interest.
Results: Twenty compounds, with β-pinene being the major constituent (23.4 %), were identified in EO. EO exhibited fungicide potential, with MFC values in the range of 0.06 to 125 μg mL−1, which were lower than those of the reference drugs against Trichophyton rubrum check for this species in other resources CCT 5507 URM1666 and Microsporum canis check for this species in other resources ATCC 32903. MIC range for the compounds was from 0.03 to 125 μg mL−1 for five strains of the fungi evaluated. For Trichophyton mentagrophytes check for this species in other resources ATCC 11481 and Epidermophyton floccosum check for this species in other resources CCFIOC 3757, MIC was ≥ 1000 μg mL−1. Flattening, distortions, and shrinkage were observed in the SEM images of structures of the five fungal species that were subjected to the action of the EO.
Conclusion: The results indicate that EO has antifungal activity against filamentous fungi and may be developed as an alternative for the treatment of onychomycosis.

Keywords
Baccharis trimera; Fungi; Onychomycosis; Dermatophytes; Antifungal

 
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