Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 14, No. 12, 2015, pp. 2155-2162
Bioline Code: pr15283
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 14, No. 12, 2015, pp. 2155-2162
© Copyright 2015 - Tropical Journal of Pharmaceutical Research
Eudragit E100 and Polysaccharide Polymer Blends as Matrices for Modified-Release Drug Delivery I: Physicomechanical Properties|
Ngwuluka, Ndidi C.; Nep, Elijah I.; Ochekpe, Nelson A.; Odumosu, Patricia O. & Olorunfemi, Patrick O.
Purpose: To compare the effects of two states of polymer/polymer blending (dry and
aqueous/lyophilized) on the physicomechanical properties of tablets, containing blends of locust bean
gum (LB) with Eudragit® E100 (E100) and sodium carboxymethylcellulose (SCMC) as matrices.
Methods: LB, SCMC and E100 were blended in their dry (as purchased) state or modified by aqueous
blending and subsequent lyophilization, prior to use as matrices in tablets. The polymer blends were
characterized by infra-red spectroscopy (FTIR), flow and compressibility tests, as well as
physicomechanical analysis of their tablets.
Results: No significant variations were noticeable in the FTIR peaks of the individual polymers in the
dry and the aqueous/lyophilized states. Aqueous/lyophilized blending of the polymers resulted in better
flow properties. The aqueous/lyophilized matrices were denser with improved mechanical strength and
the tablets were harder than those produced from dry blended polymers.
Conclusion: Dry blending of LB with E100 and SCMC greatly improved the physicomechanical
properties of the tablets. This was further enhanced by aqueous/lyophilized blending.
Drug delivery; Polymer blend; Eudragit; Locust bean gum; Levodopa; Sodium carboxymethylcellulose; Matrix; Physicomechanical properties
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