Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 12, No. 2, 2015, pp. 2163-2170
Bioline Code: pr15284
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 12, No. 2, 2015, pp. 2163-2170
© Copyright 2015 - Tropical Journal of Pharmaceutical Research
Eudragit E100 and Polysaccharide Polymer Blends as Matrices for Modified-Release Drug Delivery II: Swelling and Release Studies|
Ngwuluka, Ndidi C.; Nep, Elijah I.; Ochekpe, Nelson A.; Odumosu, Patricia O. & Olorunfemi, Patrick O.
Purpose: To compare the effects of two states of polymer/polymer blending (dry and
aqueous/lyophilized) of locust bean gum with Eudragit® E100 and sodium carboxymethylcellulose on
swelling and drug (levodopa) release from their tablet matrices.
Methods: Sodium carboxymethylcellulose (SCMC), Eudragit® (E100) and locust bean (LB) were
blended in their dry (as purchased) state or modified by aqueous blending and subsequent lyophilization
prior to use as tablet matrices. The tablets were evaluated for swelling and in vitro drug release.
Furthermore, in vivo absorption was predicted from the in vitro release data by convolution method.
Results: E100 matrices exhibited little or no swelling while the matrices of SCMC and LB and their
blends exhibited a degree of swelling > 180 %. Aqueous blending and lyophilization modulated the rate
of release from matrices formulated with LB, SCMC and their polymer/polymer blends. Drug release
profiles of the lyophilized polymer/polymer blends matrices were dissimilar to those of the dry
polymer/polymer blends. Formulations F1aq, F2aq and F3aq exhibited fairly uniform absorption in the
first 8 h, indicating the possibility of producing a steady delivery of drug.
Conclusion: Polymer blending of LB, SCMC and E100, achieved by aqueous blending and
lyophilization, enhances the performance of the matrices thereby exhibiting controlled levodopa release
with no burst effect and the tablets retained their three-dimensional network.
Controlled release; Drug delivery; Eudragit; Locust bean; Levodopa; Matrix; Polymer blend; Sodium carboxymethylcellulose
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