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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 14, No. 12, 2015, pp. 2255-2261
Bioline Code: pr15297
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 14, No. 12, 2015, pp. 2255-2261

 en Biological Activities of three Nigerian Spices - Laurus nobilis check for this species in other resources Linn, Murraya koenigii check for this species in other resources (L) Spreng and Thymus vulgaris check for this species in other resources Linn
Kazeem, Mutiu Idowu; Ashafa, Anofi Omotayo Tom & Nafiu, Mikhail Olugbemiro

Abstract

Purpose: To evaluate the biological properties of polyphenol extracts of three spices – Laurus nobilis check for this species in other resources (bay), Murraya koenigii check for this species in other resources (curry) and Thymus vulgaris check for this species in other resources (thyme) from Lagos, Nigeria.
Methods: Acetone extracts of these spices were subjected to bovine serum albumin (BSA)-glucose antiglycation, 1, 1-diphenyl-2-picrylhydrazyl (DPPH) and superoxide anion radical scavenging assays. Brine-shrimp lethality and phytotoxicity tests were also performed on the extracts (10 – 1000 μg/mL).
Results: The extract of T. vulgaris had the highest antiglycation effect with 50 % inhibitory concentration (IC50) of 0.02 mg/mL, as well as antioxidant potential with IC50 of 0.10 and 0.06 mg/mL for DPPH and superoxide anion radical scavenging assays, respectively (p < 0.05). On the other hand, all the extracts exhibited weak cytotoxicity with 50 % lethal dose (LD50) ranging from 1000 – 2000 μg/mL, and for phytotoxicity, LD50 ranged from 640 – 1640 μg/mL).
Conclusion: Acetone extracts of bay, curry and thyme displayed good antiglycation as well as antioxidant potential and are safe for consumption. However, of all the spices, thyme exhibited the best activity as an antioxidant and antiglycation agent.

Keywords
Glycation; Hyperglycemia; Polyphenols; Spices; Bay; Curry; Thyme

 
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