Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 15, No. 1, 2016, pp. 107-113
Bioline Code: pr16015
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 15, No. 1, 2016, pp. 107-113
© Copyright 2016 - Tropical Journal of Pharmaceutical Research
Chemical Composition and Antimicrobial Activity of Geniosporum rotundifolium Briq and Haumaniastrum villosum (Bene) AJ Paton (Lamiaceae) Essential Oils from Tanzania|
Ngassapa, Olipa D.; Runyoro, Deborah K. B.; Vagionas, Konstantinos; Graikou, Konstantia & Chinou, Ioanna B.
Purpose: To determine the chemical composition and antimicrobial potential of essential oils from two
aromatic plants of Tanzania, Geniosporum rotundifolium Briq. and Haumaniastrum villosum (Benè) A.J.
Method: Essential oils from the aerial parts of the plants were extracted by hydro-distillation for 3 h
using a Clevenger type of apparatus. The constituents were analyzed by gas chromatography – mass
spectrometry (GC/MS).The minimum inhibitory concentrations of the essential oils were determined for
eight bacterial strains and three pathogenic fungi using agar dilution method.
Results: The constituents of G. rotundifolium oil were mainly oxygenated derivatives of mono- and
sesquiterpenes; spathulenol (12.46 %), α-terpineol (4.65 %) and germacrene-D (3.71 %) were the most
abundant. Those of H. villosum oil were predominantly sesquiterpenes (72.61 %) with caryophyllene
oxide (19.01 %), humulene epoxide II (11.95 %), β-bourbonene (5.7 %), α-humulene (5.63 %) and β-
caryophyllene (5.39 %) being more abundant. The oil of G. rotundifolium exhibited weak to moderate
activity against the bacterial species but showed no activity against the test fungi. However, H. villosum
oil showed very promising activity against all the test microorganisms (MIC 0.08 – 10.34 mg/mL).
Conclusion: The major components of G. rotundifolium essential oil were oxygenated derivatives of
mono- and sesquiterpenes whereas those of H. villosum were sesquiterpenes. All tested
microorganisms were susceptible to H. villosum oil.
Geniosporum rotundifolium; Haumaniastrum villosum; Essential oils; Chemical composition; Antimicrobial activity
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