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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996 EISSN: 1596-5996
Vol. 15, No. 1, 2016, pp. 115-119
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Bioline Code: pr16016
Full paper language: English
Document type: Research Article
Document available free of charge
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Tropical Journal of Pharmaceutical Research, Vol. 15, No. 1, 2016, pp. 115-119
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Effect of Low Level Cadmium Exposure on Superoxide Dismutase Activity in Rat
Ogunrinola, Olabisi O.; Wusu, Dorcas A.; Fajana, Olusegun O.; Olaitan, Samuel N.; Smith, Zainab O. & Bolaji, Abdul-Rahman I.
Abstract
Purpose: To investigate the effect of low level cadmium (Cd) exposure on the activity of superoxide
dismutase (SOD) in rat.
Methods: Thirty-two male albino rats were divided into four groups of eight animals each. Group one
received distilled water and served as control. The other three groups were exposed to 100, 200 and
300 ppm cadmium doses, respectively, in their drinking water for 6 weeks. At the end of 6 weeks, blood,
brain and liver were removed from the animals and SOD activities were investigated
spectrophotometrically at 480 nm.
Results: The data revealed a significant (p < 0.05) decrease in organ weight of the exposed rats, and
with the highest cadmium accumulation in liver ranging from 2.99 ± 0.20 μg Cd/g tissue in control to
34.57 ± 2.06 μg Cd/g tissue for the 300 ppm dose group. Exposure to cadmium resulted in significant (p
< 0.05) decrease in SOD activity in plasma, erythrocytes, brain and liver in a dose-dependent manner
compared to control. The data showed a negative correlation between tissue cadmium and SOD in
plasma, erythrocyte and brain. While positive associations were observed between blood and tissue
(brain and liver) cadmium and SOD, a significant (p < 0.01), negative correlation was found between
tissue cadmium and SOD.
Conclusion: As Cd dose increase, plasma, erythrocyte, brain and liver SOD activities decrease. This
might affect the maintenance of the normal body physiological conditions.
Keywords
Cadmium; Superoxide dismutase; Liver; Brain; Toxicity; Environmental Contaminant
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