|
Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996 EISSN: 1596-5996
Vol. 15, No. 1, 2016, pp. 167-172
|
Bioline Code: pr16023
Full paper language: English
Document type: Research Article
Document available free of charge
|
|
Tropical Journal of Pharmaceutical Research, Vol. 15, No. 1, 2016, pp. 167-172
en |
Physicochemical Characterization of Inclusion Complex of Catechin and Glucosyl-β-Cyclodextrin
Li, Bin; Zhang, Wenbo & Ma, Hanjun
Abstract
Purpose: To investigate the suitability of glucosyl-β-cyclodextrin (G-β-CD) to form inclusion complex
with catechin, and characterize the physicochemical properties of the inclusion complex of catechin and
G-β-CD.
Methods: Catechin and G-β-CD was mixed in water at the same molar ratio, stirred at 20 °C for 48 h
and lyophilized to obtain the complex. Its physicochemical properties were investigated by ultravioletvisible
spectrometry (UV), Fourier transform infrared spectroscopy (FT-IR), scanning electron
microscopy (SEM), X-ray diffractometry (XRD) and differential scanning calorimetry (DSC).
Results: The characteristic UV absorption peaks for catechin, the physical mixture and the complex
occurred at 279 nm. There was no significant difference between the IR spectra of the physical mixture
and the complex. SEM and XRD data indicate that catechin was molecularly distributed in G-β-CD
matrix and lost its crystallinity in the process. DSC indicate that the heat stability of catechin was
significantly improved by complexing with G-β-CD.
Conclusion: Catechin can efficiently interact with G-β-CD to form a complex by freeze-drying method.
The complex of catechin and G-β-CD resulted in the changes in some of the characteristic spectral and
thermal properties of the former. Furthermore, the heat stability of catechin is significantly improved.
Keywords
Catechin; Glucosyl-β-cyclodextrin; Complex; Physicochemical property
|
|
© Copyright 2016 - Tropical Journal of Pharmaceutical Research Alternative site location: http://www.tjpr.org
|
|