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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 15, No. 2, 2016, pp. 215-220
Bioline Code: pr16029
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 15, No. 2, 2016, pp. 215-220

 en Formulation of a New Generation of Liposomes from Bacterial and Archeal Lipids
Ameri, Abdulghani; Moghimipour, Eskandar; Ramezani, Zahra; Kargar, Mohammad; Hashemitabar, Mahmood; Saremy, Sadegh & Handali, Somayeh

Abstract

Purpose: To evaluate the application of bacterial liposomes and archaeosomes as a novel drug delivery system for in vitro cytoplasmic delivery of molecules into cancer cells.
Methods: Bacterial membrane lipids were extracted using chloroform and methanol. Bacterial liposomes and archaeosomes of E. coli check for this species in other resources , Acidianus brierleyi check for this species in other resources and Sulfolobus acidocaldarius check for this species in other resources were prepared using film method and their trailing in cancer cells (HT-29) was evaluated by carboxyfluorescein (CF). Their morphological characteristics were assessed by atomic force microscopy (AFM).
Results: At 37 °C, the liposomes and archaeosomes interacted with cell membranes predominantly by fusion and endocytosis. The AFM images showed uniform and dispersed distribution of the liposomes.
Conclusion: The findings demonstrate that bacterial liposomes and archaeosomes may be useful as drug delivery carriers for the treatment of cancer.

Keywords
Liposome; Archaeosome; E. coli; Acidianus brierleyi; Sulfolobus acidocaldarius; Cancer; HT-29 cell; Atomic force microscopy; Film method

 
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