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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 15, No. 2, 2016, pp. 221-229
Bioline Code: pr16030
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 15, No. 2, 2016, pp. 221-229

 en Preparation and Evaluation of Alcohol-Alkaline-Treated Rice Starch as a Tablet Disintegrant
Boonwatcharapan, Yanisa; Srisuk, Pathomthat; Palladino, Pasquale; Sutthiparinyanont, Saengrawee & Chitropas, Padungkwan


Purpose: To prepare and characterize alcohol-alkaline modified rice starch (MRS) as a disintegrant for tablets.
Methods: The preparation of MRS was carried out using 3 M NaOH and 40 % ethanol solution. Characterization carried out for MRS include morphology, swelling capacity, thermal and pasting properties. Direct-compressed tablets (DCT) containing either propranolol hydrochloride (PPNL) or hydrochlorothiazide (HCTZ) were evaluated for hardness, friability, disintegration time and drug release.
Results: The microstructure of MRS was different in shape and dimension from that of rice starch (RS). The absence of gelatinization endotherm and FT-IR spectral peak for MRS correlated with change in MRS structure and arrangement. MRS showed significantly higher swelling capacity (p < 0.05) than RS, and also proved to be a disintegrant in DCT. The disintegration time of the tablets containing MRS was lower in the presence of large particles (3.55 ± 0.56 min); high content of MRS (1.03 ± 0.06 min); low content of lubricant (3.16 ± 0.44 min); water soluble filler (1.55 ± 0.16 min for Super-tab®); and model drug (0.84 ± 0.09 min for HCTZ) (p < 0.05).
Conclusion: MRS exhibits improved water solubility and swelling capacity compared with RS, and is thus a good disintegrant for direct-compressed tablet formulations, especially in the presence of water insoluble fillers.

Rice starch; Alcohol-alkaline treatment; Disintegrant; Directly-compressed tablet; Insoluble fillers

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