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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 15, No. 2, 2016, pp. 259-266
Bioline Code: pr16034
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 15, No. 2, 2016, pp. 259-266

 en Hepatoprotective Effect of Pandanus odoratissimus check for this species in other resources L Inflorescence Extracts in Acetaminophen-treated Guinea Pigs
El-Shaibany, Amina; AL-Habori, Molham; Al-Massarani, Shaza; El-Gamal, Ali; Al-Ajami, Ali & Al-Adhl, Adenan

Abstract

Purpose: To investigate the hepatoprotective activity of methanol extracts of peduncles, flowers and spathes of Pandanus odoratissimus check for this species in other resources L. inflorescence in acetaminophen-induced hepatotoxicity in guinea pigs.
Methods: The animals were randomly assigned to 9 groups (3 animals per group) and treated orally for 10 consecutive days. Group 1 served as normal control and received distilled water (1 ml/kg); groups 2 - 4 received methanol extracts of peduncle, flower, and spathes of P. odoratissimus L. (500 mg/kg), respectively, in the absence of acetaminophen (APAP); group 5 served as hepatotoxic control and received APAP (3 g/kg) on days 1 and 2; group 6 served as standard treatment group and received silymarin (100 mg/kg) + 3 g/kg APAP on days 1 and 2; groups 7 - 9 received methanol extracts of peduncle, flower, and spathes of P. odoratissimus L. (500 mg/kg) respectively + 3 g/kg APAP on days 1 and 2. Serum enzyme activities (AST, ALT, ALP) and total bilirubin were determined. Histopathological examinations of the liver were also carried out.
Results: The methanol extract of the peduncle alleviated the liver damage induced by APAP as evident by the improved histopathology picture similar to that of silymarin which presented with only mild hydropic and fatty changes. The extract also reduced the liver enzymes - AST, ALT and ALP - by 42, 50 and 59 %, respectively (p < 0.05), but the reduction (32 %) in total bilirubin was not significant 32 %. On the other hand, the flower extract only lowered AST and ALP by 31 and 48 % (p < 0.05), respectively, while the reduction in ALT and total bilirubin by 33 and 18 % respectively, was not significant.
Conclusion: P. odoratissimus L. peduncle has potential hepatoprotective activity against APAPinduced hepatotoxicity in guinea pigs.

Keywords
Pandanus odoratissimus L.; Peduncle; Flowers; Hepatoprotection; Acetaminophen; Guinea pigs

 
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