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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 15, No. 3, 2016, pp. 461-467
Bioline Code: pr16062
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 15, No. 3, 2016, pp. 461-467

 en Effect of Probiotics on Serum Biochemical and Blood Constituents in Chicken Challenged with Salmonella enterica check for this species in other resources Subsp Typhimurium
Abudabos, Alaeldein M.; Murshed, Mutee A.; Qaid, Mohammed M. & Abdelrahman, Abdelrahman G.


Purpose: To examine the effects of two commercial probiotics (Toyocerin and CloSTAT) on serum enzyme activities, and hematological and biochemical indices of broiler chickens challenged with Salmonella enterica check for this species in other resources serovars Typhimurium (ST).
Methods: The chicks received one of the following treatments at 0 day of age: T1 = control group, unmedicated diet, unchallenged birds, (negative control); T2 = unmedicated diet + bacterial challenge (positive control); T3 = medicated diet with neoxyval (0.05 g/kg diet) + bacterial challenge (NEOX); T4 = toyocerin (1 g/kg diet) + bacterial challenge (Toyocerin); and T5 = CloSTAT (1 g/kg diet) + bacterial challenge (COLS). Blood samples were withdrawn from 7 selected chicks in each treatment at 7, 21, 28, 35 and 42 days of age, and analyzed for total protein, albumin and globulin concentration, and the albumin: globulin ratio computed. Glutamate-oxaloacetate transaminase (GOT) and glutatamate pyruvate transaminase (GPT) levels in serum were measured on days 7 and 42.
Results: The results revealed that albumin (p < 0.001), globulin (p < 0.001) and albumin: globulin ratio (p < 0.001) were influenced by the time of blood collection. Globulin increased significantly after ST challenge while albumin decreased significantly. Glutamate-oxaloacetate transaminase (GOT) after ST challenge was affected by treatment (p < 0.05). Higher levels were obtained from birds which had received NEOX or positive control, compared to negative control group.
Conclusion: Salmonella challenge affects serum albumin, globulin and GOT enzyme. The results obtained suggest that the probiotic, Toyocerin, mitigates the negative effects of Salmonella challenge.

Bacillus subtilis PB6; Bacillus Cereus var. toyoi; Probiotics; Liver enzymes; Hematology; Salmonella enterica

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