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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 15, No. 3, 2016, pp. 469-474
Bioline Code: pr16063
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 15, No. 3, 2016, pp. 469-474

 en Evaluation of Antiproliferative Activity of Some Traditional Anticancer Herbal Remedies from Jordan
Abu-rish, Eman Y.; Kasabri, Violet N.; Hudaib, Mohammad M.; Mashalla, Sundus H.; AlAlawi, Loay H.; Tawaha, Khaled A.; Mohammad, Mohammad K.; Mohamed, Yehia S. & Bustanji, Yasser K.

Abstract

Purpose: To evaluate the in vitro antiproliferative activity of the extracts of three plants from Jordan flora against a panel of human tumor cell lines representing the most common types of cancer in Jordan, breast, colorectal and skin cancers.
Methods: The methanol extracts of the aerial parts of the three plants ( Arbutus andrachne check for this species in other resources L., Chrysanthemum coronarium check for this species in other resources L., and Teucrium polium L.) were prepared and assessed for antiproliferative activity against six human tumor cell lines (A375.S2, WM1361A, CACO-2, HRT18, MCF-7, T47D) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide MTT cell proliferation assay.
Results: C. coronarium extract, at the concentration range of 25 to 400 μg/mL, significantly inhibited (10 – 50 %) the proliferation of the 6 cell lines in a dose-dependent manner, whilst the extracts of the other two plants exhibited weak antiproliferative activity (2 – 10 % inhibition). The half-maximal inhibitory concentration (IC50) values of C. coronarium extract against the six cell lines were in the range of 75.8 to 138.5 μg/mL.
Conclusion: The methanol extract of the aerial parts C. coronarium possesses a relatively potent antiproliferative activity and therefore might be a potential source of natural compounds that can be developed into new antineoplastic agents.

Keywords
Antiproliferative; Arbutus andrachne L.; Chrysanthemum coronarium L.; Teucrium polium L. Jordan flora; Medicinal plants; Cancer; Antineoplastic

 
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