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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 15, No. 3, 2016, pp. 513-519
Bioline Code: pr16069
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 15, No. 3, 2016, pp. 513-519

 en Clematis chinensis check for this species in other resources Extract Protects against Diabetic Nephropathy in Rats
Xu, Liang; Zhao, Bing; Sun, Jing; Wang, Hai-ping & Wang, Rong

Abstract

Purpose: To study the effect of Clematis chinensis check for this species in other resources extract (CCE) on diabetic nephropathy in rats.
Methods: Eight-week old male Wistar rats were injected with streptozotocin to induce diabetes. The effects of CCE(250 or 500 mg/kg) on renal function index, fasting blood glucose (FBG), blood fat, oxidation index, and pathological kidney changes for 3 weeks were compared to those of the positive control drug, captopril.
Results: At 12 weeks, CCE(500 mg/kg) treatment had significantly decreased serum blood urea nitrogen (BUN, 12.61 ± 1.42 mmol/L), serum creatinine (SCr, 84.64 ± 6.37 μmol/L), creatinine clearance (CCr, 0.88 ± 0.10 mmol/L), interleukin-6 (IL-6, 297.56 ± 19.62 pg/mL), urinary albumin, urinary albumin excretion rate (UAER, 11.68 ± 0.97 μg/min), kidney hypertrophy index (kidney weight/body weight, 0.58 ± 0.03%) and FBG (11.51 ± 0.96 mmol·L-1). It significantly decreased triglyceride (TG, 0.26 ± 0.05 mmol/L), total cholesterol (TC, 1.52 ± 0.06 mmol/L) and low-density lipoprotein-cholesterol (LDL-c, 0.71 ± 0.06 mmol/L) levels and increased high-density lipoprotein-cholesterol (HDL-c, 0.65 ± 0.05 mmol/L). CCE treatment also significantly decreased malondialdehyde (MDA, 16.14 ± 1.24 nmol/mgprot) levels and increased superoxide dismutase (SOD, 95.17 ± 4.06 U/mgprot) and glutathione peroxidase (GSHPx, 154.33 ± 11.76 mmol/L) (both p < 0.05). Finally, CCE reduced the degree of glomerular basement membrane and renal tubular thickening and swelling in diabetic rats.
Conclusion: CCE has a significant inhibitory effect on diabetic nephropathy-induced renal injury in rats.

Keywords
Clematis chinensis; Diabetic nephropathy; Renal function; Pathological morphology

 
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