Changes in Nitric Oxide Level and Thickness Index of Synovial Fluid in Osteoarthritis Patients following Intraarticular Injection of Sodium Hyaluronate|
Li, Laifeng; Wang, Hui; Li, Demin & Zhang, Cunming
Purpose: To monitor the changes in nitric oxide levels and synovium thickness index in synovial fluid
following intra-articular injection of sodium hyaluronate.
Methods: One hundred patients diagnosed with osteoarthritis of the knee from April 2014 to January
2015 in The Third Hospital of Jinan, Jinan, Shandong, China were selected and categorized into three
phases; namely, mild, moderate and severe. Patients received a 20 mL sodium hyaluronate injection
into the articular cavity of the knee once per week for 15 weeks, with continuous observation. The
Visual Analogue Scale (VAS) and Western Ontario and McMaster University Osteoarthritis Index
(WOMAC) scores were recorded after five weeks. A total of 56 patients (78 knees) remaining in serious
condition after 5 weeks were divided into mild, moderate, and severe groups and treated with sodium
hyaluronate once a week. Internationally reorganized VAS and WOMAC scores were adopted as
clinical observation indices to indicate the curative effect of sodium hyaluronate among the 56 patients
after 15 weeks of treatment. The conditions of the patients in the two phases were compared.
Results: After 5 weeks of treatment, treatment effective rate in the mild, moderate and severe groups
was 72.92, 66.10 and 28.57 %, respectively, with an overall effective rate of 78 %. After 15 weeks of
treatment, treatment effective rate in mild, moderate, and severe groups was 96.77, 95.45 and 66.67 %,
respectively, with an overall effective rate of 67.95 %.
Conclusions: Clinically curative effect of sodium hyaluronate is significant for mild and moderate phase
patients after intra-articular injection of sodium hyaluronate, while the effect is insignificant in severe
patients. Thus, sodium hyaluronate can effectively improve nitric oxide levels in synovial fluid, reduce
synovium thickness, enhances articular cavity lubrication and effectively alleviates disease severity.
Osteoarthritis; Knee; Intra-articular injection; Sodium hyaluronate; Nitric oxide; Synovium thickness; WOMAC