Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 15, No. 4, 2016, pp. 729-733
Bioline Code: pr16097
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 15, No. 4, 2016, pp. 729-733
© Copyright 2016 - Tropical Journal of Pharmaceutical Research
Dipsacus asperoides (Xue Duan) inhibits spinal cord injury-induced inflammatory responses in rats|
Chen, Liang & Guo, Wei-Chun
To investigate the effect of Dipsacus asperoides (Xue Duan), a traditional Chinese medicine,
on rats with spinal cord injury (SCI).
In this study a total of 40 adult rats were used after inducing SCI where Xue Duan was
applied on experimental group and phosphate-buffered saline (PBS) was administered in corresponding
control groups. Intraperitoneal administration of both compounds for a period of four weeks (28 days)
was carried out at a dose of 10 mg/kg/day. Bright field microscopy was performed on the tissues.
Bright Field microscopy of tissue sections showed significant reduction in cavity area that
resulted from injury, that is from 0.19 ± 0.05 mm2 to 0.09 ± 0.03 mm2 (p < 0.01) in untreated and treated
groups respectively. Similarly western blotting results showed a decrease in the expression of NF-kB
p65 and I-kBα (p < 0.01). These two compounds are important in increasing secondary pathophysiology
in SCI. The results for MPO activity also revealed significantly reduced infiltration of leukocytes to the
injury site (p < 0.01).
This study reveals the positive effect of the plant material in reducing inflammation in rats
with traumatic SCI.
IKK/NF-kB pathway; Spinal cord injury; Xue Duan; MPO activity; Inflammation; Dipsacus asperoides
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