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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 15, No. 4, 2016, pp. 773-779
Bioline Code: pr16103
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 15, No. 4, 2016, pp. 773-779

 en Indigofera tinctoria Linn check for this species in other resources (Fabaceae) attenuates cognitive and behavioral deficits in scopolamine-induced amnesic mice
Kim, Jong-Bo; Kopalli, Spandana Rajendra & Koppula, Sushruta

Abstract

Purpose: To investigate the cognition-enhancing effects of aqueous extract of Indigofera tinctoria Linn check for this species in other resources (ITE, Fabaceae) in experimental amnesic mice.
Methods: Scopolamine (2 mg/kg, i.p.) was used to induce amnesia in mice. The cognitive-enhancing activity of the ITE (5, 10 and 20 μg/mL) was studied by passive avoidance response, elevated plus maze and Y-maze behavioral paradigm in normal and scopolamine-induced amnesic mice. Antioxidant activities were also determined based on the ability of ITE to inhibit lipid peroxide, superoxide and hydroxyl radicals.
Results: Scopolamine-induced cognitive deficits were significantly reversed by ITE (p < 0.001 at 20 mg/kg) in a dose-dependent fashion in all the behavioral paradigms tested. Furthermore, ITE dosedependently scavenged lipid peroxide, superoxide and hydroxyl free radicals with 50 % inhibition concentration (IC50) of 7.28 ± 0.37, 5.25 ± 0.28 and 7.62 ± 0.43 μg/mL, respectively.
Conclusion: ITE possesses cognitive-enhancing properties in amnesic mice due to its potent antioxidant action.

Keywords
Indigofera tinctoria; Scopolamine; Lipid peroxidation; Amnesia; Antioxidant; Cognition

 
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