Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 15, No. 4, 2016, pp. 841-846
Bioline Code: pr16113
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 15, No. 4, 2016, pp. 841-846
© Copyright 2016 - Tropical Journal of Pharmaceutical Research
Use of BARD scoring system in non-alcoholic fatty liver disease patients and its correlation with ultrasonographic grading in Gizan, Saudi Arabia|
Ageely, Hussein M.; Elmakki, Erwa M.; Bani, Ibrahim A.; Mohamed, Husam O.; Taher, Asim A.; Hadi, Talal O.; Abdalla, Saif Elden B.; Hendi, Ali M. & Mahfouz, Mohamed Salih
To assess the efficacy of the BARD scoring system in Saudi non‐alcoholic fatty liver disease
(NAFLD) patients attending Gizan General Hospital and to identify the clinical variables associated with
advanced fibrosis. .
The cross-sectional study involved 120 patients aged ≥ 18 years who attended the
Ultrasound Department of Gizan General Hospital, Gizan, Saudi Arabia, during January – June 2013.
BARD scoring system comprised the following variables: body mass index (BMI) ≥ 28 = 1 point,
aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio ≥ 0.8 = 2 points, and type 2
diabetes mellitus = 1 point.
Patients with advanced fibrosis were older (55.0 years) than patients with no/mild fibrosis
(48.6 years), albeit not significantly so. A higher BMI was associated with advanced fibrosis in males,
females and all study participants (p = 0.013, 0.016 and 0.001, respectively). Advanced fibrosis was
more common in older patients with a higher weight to height ratio. Logistic regression suggested that
age ≥ 50 years was associated with a 2.52-fold increase in the risk of advanced fibrosis, but this did not
have a significant clinical impact (p = 0.087). BMI > 28 was associated with a 26.73-fold increased risk
of advanced fibrosis, while AST/ALT ≥ 0.8 was associated with an 18.46-fold increased risk of advanced
liver fibrosis (p = 0.002 and 0.006, respectively).
The major risk factors for advanced fibrosis using BARD scoring system in patients with
NAFLD were old age, BMI > 28, and AST/ALT ≥ 0.8. In addition, grade 3 ultrasonographic fatty liver
significantly correlated with advanced fibrosis.
BARD score; Body mass index; Ultrasonographic grading; Non-alcoholic fatty liver disease; Fibrosis score
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