Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 15, No. 6, 2016, pp. 1313-1320
Bioline Code: pr16174
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 15, No. 6, 2016, pp. 1313-1320
© Copyright 2016 - Tropical Journal of Pharmaceutical Research
Factors associated with hypoglycemia episodes in hospitalized type 2 diabetes mellitus patients in a tertiary health facility in Malaysia|
Huri1,2*,, Hasniza Zaman; Aziz1,, Muhammad Irfan Abdul; Vethakkan3, Shireene Ratna & Widodo1, Riyanto Teguh
Purpose: To determine the factors associated with severity of hypoglycemia in hospitalized type 2
diabetes mellitus patients in a tertiary health facility in Malaysia.
Methods: This retrospective study involved 207 hospitalised T2DM patients with hypoglycaemia
episodes from January 2008 to December 2012 and was conducted in University Malaya Medical
Centre, Petaling Jaya, Malaysia. Patients were classified into 2 groups, viz, those who had
hypoglycaemia on admission and those who had hypoglycaemia during hospital stay. Patients with
hypoglycemia on admission were those admitted due to hypoglycemia while patients with hypoglycemia
during hospital stay were those admitted due to other causes but subsequently developed
hypoglycemia during hospitalization.
Results: The results for the 207 patients investigated show that most of the patients (72.2 %) were
asymptomatic during hypoglycemic episodes. The majority of the episodes (57.4 %) experienced by the
patients were mild hypoglycemia (< 3.9 mmol/L). Old age (p = 0.011) and presence of stroke (p = 0.033)
were found to be significantly associated with severe hypoglycemia (< 2.2 mmol/L) while concurrent use
of opioid (p = 0.008) was associated with mild hypoglycemia.
Conclusion: The identification of the underlying factors associated with severity of hypoglycemia may
help in preventing and resolving hypoglycemia in T2DM patients.
Hypoglycemia episodes; Type 2 diabetes; Associated factors; Elderly, Stroke; Opiods
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