Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 15, No. 6, 2016, pp. 1341-1348
Bioline Code: pr16178
Full paper language: English
Document type: Review Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 15, No. 6, 2016, pp. 1341-1348
© Copyright 2016 - Tropical Journal of Pharmaceutical Research
Natural antioxidant vitamins: A review of their beneficial roles in management of diabetes mellitus and its complications|
Ayeleso, Ademola; Brooks, Nicole; Oguntibeju, Oluwafemi & Mukwevho, Emmanuel
Diabetes mellitus is a complex and progressive metabolic disease which is associated with multiple
complications. Chronic hyperglycaemia is the defining characteristic of diabetes mellitus.
Hyperglycaemia leads to generation of free radicals and induces oxidative stress, which has become
the chief factor that leads to diabetic complications. This review supports the use of antioxidant vitamins
as therapeutic agents in the management of diabetes mellitus and its complications, and also provides
an insight into the potential pharmacological effects of natural antioxidant vitamins in diabetic conditions.
These antioxidant vitamins can be used as safe supplements to manage the occurrence and
complications of the disease. Selected studies have reported on the beneficial effects of antioxidant
vitamins in experimental models. The involvement of oxidative stress in diabetes and its complications
has made the use of natural antioxidant vitamins (free radical scavengers) from plants inevitable as they
may be very effective and safer in the management of diabetes.
Antioxidant; Oxidative stress; Vitamins; Diabetes mellitus
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