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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 15, No. 7, 2016, pp. 1459-1463
Bioline Code: pr16193
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 15, No. 7, 2016, pp. 1459-1463

 en Anti-hyperprolactinemic effect of Ficus pumila check for this species in other resources Linn extract in rats
He, Xiu-guo; Fan, Jiu-bo; Liu, Hai-ju & Xia, Ning

Abstract

Purpose: To investigate the anti-hyperprolactinemic effect of Ficus pumila check for this species in other resources Linn. extract (FPLE) in rats.
Methods: Hyperprolactinemic rats were generated by subcutaneous injection of metoclopramide dihydrochloride (50 mg/kg). A high dose (800 mg/kg), moderate dose (400 mg/kg), or low dose (200 mg/kg) of FPLE was administered into the stomach of hyperprolactinemic rats for 30 days, after which serum sex hormones and pituitary prolactin-positive cell number and mRNA expression were measured.
Results: FPLE had a significant effect on measures of hyperprolactinemia. Compared with hyperprolactinemic rats without FPLE treatment, hyperprolactinemic rats that received a high dose of FPLE showed altered serum estradiol, progesterone, prolactin, follicle-stimulating hormone, and luteinizing hormone levels (p < 0.05), as well as decreased pituitary prolactin-positive cell number (p < 0.05) and mRNA expression (p < 0.05).
Conclusion: FPLE can potentially be used as an anti-hyperprolactinemia treatment but further studies are required to ascertain its suitability.

Keywords
Ficus pumila; Hyperprolactinemia; Prolactin; Metoclopramide; Estradiol; Follicle-stimulating and luteinizing hormones; Sex hormones

 
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