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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 15, No. 8, 2016, pp. 1651-1657
Bioline Code: pr16216
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 15, No. 8, 2016, pp. 1651-1657

 en Aqueous root extract of Dicoma anomala check for this species in other resources Sond ameliorates isoproterenol–induced myocardial infarction in Wistar rats
Balogun, Fatai O. & Ashafa, Anofi O.T.

Abstract

Purpose: To evaluate the protective potentials of the aqueous root extract of Dicoma anomala check for this species in other resources (AQRED) against isoproterenol (ISP)-induced myocardial damage in Wistar rats.
Methods: Myocardial damage was induced in Wistar rats by isoproterenol (60 mg/kg body weight, b.w.) Various concentrations (125, 250, and 500 mg/kg b.w.) of AQRED and their effects on the rats’ feed and water intake, body weight changes, serum enzymes, including aspartate transaminase (AST), alanine transaminase (ALT) creatinine phosphokinase (CPK), as well as tissue antioxidant enzymes, including catalase (CAT), glutathione peroxidase (GP) and lipid peroxidation, during a 30-day experimental period were examined.
Results: ISP-treated rats showed no significant (p > 0.05) effect on the feed, water and body weight but increased significantly (p < 0.05) AST, ALT, CPK and lipid peroxidation while significantly reducing CAT and GP levels (p < 0.05). Treatment with different doses of AQRED significantly (p < 0.05) reversed the activity of these enzymes and cardiac lipid peroxidation towards control levels. Histopathological examination of ISP-induced myocardial rats treated with D. anomala revealed evidence of oedema and myocardial necrosis at 125 and 250 mg/kg b.w. doses, but these alterations were ameliorated or cleared at 500 mg/kg dose, suggesting attainment of maximum efficacy.
Conclusion: The findings indicate the ameliorative potential of AQRED in myocardiac disease, and therefore, could be of therapeutic significance in the management or treatment of cardiac-related diseases.

Keywords
Antioxidant enzymes; Dicoma anomala; Lipid peroxidation; Serum enzymes

 
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