About Bioline  All Journals  Testimonials  Membership  News  Donations

Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 15, No. 8, 2016, pp. 1663-1666
Bioline Code: pr16218
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 15, No. 8, 2016, pp. 1663-1666

 en Evaluation of local anesthetic and antipyretic activities of Cinchona alkaloids in some animal models
Li, Yan & Tian, Jun


Purpose: To evaluate the local anesthetic and antipyretic activities of an aqueous extract of Cinchona officinalis check for this species in other resources (C. officinalis) in experimental animal models.
Methods: Various doses of the aqueous extract was tested for its local anesthetic activity in guinea pigs and frogs using intracutaneous and plexus anesthesia, respectively. For comparison, 2 % xylocaine was used as a reference drug. The anti-pyretic activity of the aqueous extract was determined by Brewer’s yeast-induced pyrexia in rats, using aspirin (300 mg/kg) as reference.
Results: C. officinalis extract, at concentrations of 10 and 20 %, produced significant anesthetic effects, of 72.12 and 88.08 %, respectively, compared with 96.86 % anesthetic effect of 2 % standard xylocaine (p < 0.001). In the plexus model, the mean onset of anesthetic effect was recorded at 6.44 ± 0.68 min versus 3.86 ± 0.42 min (p < 0.001) for the standard drug. Single administration of the extract (100, 200 and 400 mg/kg) showed significant dose-dependent anti-pyretic activity throughout the observation period, which was comparable to the standard aspirin group.
Conclusions: The findings suggest that the aqueous extract of C. officinalis has significant local anesthetic and anti-pyretic activities in rats.

Cinchona officinalis; Antipyretic; Aspirin; Local anesthesia; Cinchona alkaloids; Xylocaine

© Copyright 2016 - Tropical Journal of Pharmaceutical Research
Alternative site location:

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2022, Site last up-dated on 19-Jan-2022.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Internet Data Center of Rede Nacional de Ensino e Pesquisa, RNP, Brazil