search
for
 About Bioline  All Journals  Testimonials  Membership  News  Donations


Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 15, No. 8, 2016, pp. 1673-1680
Bioline Code: pr16220
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 15, No. 8, 2016, pp. 1673-1680

 en Hypolipidemic effect of aqueous leaf extract of carmona microphylla G Don
Liu, Qibing; Lin, Na; Yu, Daorui; Li, Song; Xu, Qiaoqin; Qin, Xianjing; Zeng, Juntao & Zeng, Yu

Abstract

Purpose: To investigate the hypolipidemic effects of the aqueous leaf extract of Carmona microphylla (Lam.) G. Don. (CAE) in vitro and in vivo.
Methods: The lipid-lowering effect of CAE was investigated in oleic acid (OA)-induced steatosis in HepG2 liver cells, as well as in high-fat diet (HFD)- and triton WR-1339 (TRI)-induced hyperlipidemic mice. The levels of intracellular, serum and/or hepatic total cholesterol (TC); triglyceride (TG); low density lipoprotein-cholesterol (LDL-c); high density lipoprotein-cholesterol (HDL-c); hepatic superoxide dismutase (SOD) activity and malondialdehyde (MDA) were determined by oil-red O staining and appropriate kits.
Results: Treatment with CAE inhibited lipid accumulation in HepG2 cells and reduced the elevated levels of serum TC, TG and LDL-c as well as hepatic TC and TG in hyperlipidemic mice induced by HFD. CAE administration also significantly decreased arteriosclerosis index (AI) and LDL-c/HDL-c ratio, but improved oxidative status as revealed by increased hepatic SOD activity and decreased MDA level. The lipid ameliorating and antioxidative effects of CAE (600 mg/kg) were comparable to those of the standard lipid-lowering drug, sivastatin (5 mg/kg).
Conclusion: These results suggest that Condalia microphylla check for this species in other resources aqueous extract (CAE) protects against hyperlipidemia induced by HFD in mice and may find therapeutic application in hyperlipidemic patients.

Keywords
Carmona microphylla; Hyperlipidemia; Atherosclerosis; Oxidative stress; Sivastatin; Lipidlowering

 
© Copyright 2016 - Tropical Journal of Pharmaceutical Research
Alternative site location: http://www.tjpr.org

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2022, Site last up-dated on 19-Jan-2022.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Internet Data Center of Rede Nacional de Ensino e Pesquisa, RNP, Brazil