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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 15, No. 8, 2016, pp. 1691-1696
Bioline Code: pr16222
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 15, No. 8, 2016, pp. 1691-1696

 en Antinociceptive and anti-inflammatory properties of methanol fruit extract of Quercus incana check for this species in other resources in rat and mice models
Saeed, Muhammad; Gul, Farah; Zakiullah; Gilani, Syed Naeemuddin; Ur Rehman, Yaqoob; Khan, Inamullah; Muhammad, Naveed & Khan, Haroon


Purpose: To investigate the anti-inflammatory and antinociceptive properties of crude methanol fruit extract of Quercus incana check for this species in other resources (QI), as well as its acute toxicity and phytochemical profile.
Methods: Two animal models were used: Wistar rats for carrageenan-induced paw inflammation and Swiss albino mice for acetic acid-induced writhing test (hot plate method for anti-nociceptive effect). The extract was also subjected to phytochemical screening using standard procedures.
Results: The extract showed significant (p < 0.01) anti-inflammatory effect at doses of 50, 100 and 150 mg/kg. It also evoked significant anti-nociceptive activity (both peripheral and central analgesia) at all test doses (25, 50 and 100 mg/kg; p < 0.01). Acute toxicity data revealed that the extract was non-toxic up to a dose of 425 mg/kg, while phytochemical screening indicated the presence of alkaloids, flavonoids, steroids, terpenoids, anthraquinones, tannins, coumarins, reducing sugars and resins.
Conclusion: These results suggest that Quercus incana fruit contains compounds with antinociceptive and anti-inflammatory properties.

Quercus incana fruit; Antinociceptive; Anti-inflammatory; Phytochemical profile

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