Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 15, No. 8, 2016, pp. 1739-1744
Bioline Code: pr16228
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 15, No. 8, 2016, pp. 1739-1744
© Copyright 2016 - Tropical Journal of Pharmaceutical Research
Effect of corticosteroid therapy in acute pain edema caused by Herpes Zoster|
Zhang, Ruiju & Xu, Qingguo
Purpose: To evaluate the curative effect of corticosteroids in the treatment of acute pain, local edema,
and skin lesions caused by herpes zoster, and to develop some pertinent therapeutic guidelines.
Methods: A total of 48 cases of patients diagnosed with herpes zoster from 2010 to 2011 in the
dermatology clinic of Shan Dong Traffic Hospital were selected and all received the same therapy of
antiviral, pain-relieving and nerve nutrition. They were divided into a corticosteroid application group,
with 24 patients treated with corticosteroids, and a control group of 24 patients without corticosteroids.
Local swelling subsided in the corticosteroid group. The differences observed in pain relief and days
needed for blisters to dry and scab between the two patient groups were analyzed to determine
significance and, thus, assess the curative effect of corticosteroids in treatment of herpes zoster.
Results: Patients in the glucocorticosteroid application group relieved pain faster than patients in the
control group (2.38 ± 1.41 days vs 5.50 ± 3.19 days), and the difference was significant (p < 0.05). Skin
lesions of patients in the glucocorticosteroid application group healed quicker than that of patients in
control group (2.83 ± 0.87 days vs 3.54 ± 1.02 days), and the difference was remarkable (p < 0.05).
Local swelling of patients in the glucocorticosteroid application group recovered rapidly after treatment. .
Conclusion: Treatment of herpes zoster with appropriate corticosteroid isodose application can
effectively relieve acute pain and local swelling, and speed up scabbing and healing of skin lesions.
Herpes zoster; Corticosteroids; Local edema; Scab; Skin lesions; Acute pain; Blisters; Therapeutic guidelines
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