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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 15, No. 8, 2016, pp. 1781-1786
Bioline Code: pr16234
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 15, No. 8, 2016, pp. 1781-1786

 en Clinical effect of prootic and opisthotic injection of dexamethasone and gentamicin in meniere disease therapy
Guo, Xiang-Dong; Wang, Qing-Lin; Li, Ying & Zhang, Zhi-Cheng

Abstract

Purpose: To evaluate the effect of prootic and opisthotic injection of dexamethasone and gentamicin for the treatment of Meniere disease.
Methods: A total of 192 cases of Meniere disease were randomly selected from The First Affiliated Hospital of Henan University of TCM between April 2012 and December 2014. They were divided into three groups, i.e., dexamethasone (DX group), gentamicin (GM group) and normal saline (NS group). According to the test design, patients in the DX and GM groups were administered prootic and opisthotic injection of dexamethasone and gentamicin (5.5 mL once a week), respectively, for four weeks. Changes in auditory and vestibular functions, as well as control of capacity for action, were observed.
Results: On the 18th day after treatment, dizziness control rates in the DX group, GM group, and NS group were 72.73, 75.86 and 12.12 %, respectively; differences between the DX group and NS group and between the GM group and NS group were significant (p < 0.01). DX and GM groups both showed effective control of dizziness. Hearing improvement rate in DX, GM and NS groups was 39.39, 6.89 and 9.09 %, respectively (p < 0.01), indicating that only DX group showed effective hearing improvement. Improvement rate of capacity for action in DX, GM and NS groups was 75.76, 72.41 and 15.15 %, respectively; differences in the control rate of capacity for action between DX and GM groups and between GM and NS groups were significantly different (p < 0.01). Thus, DX and GM groups showed effective control of the capacity for action.
Conclusion: Prootic and opisthotic injection of dexamethasone and gentamicin is a potentially safe and effective new approach for the treatment of Meniere disease.

Keywords
Meniere disease; Dexamethasone; Dizziness; Hearing improvement; Capacity for control

 
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